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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T3664 | THZ1 | CDK7 inhibitor,THZ1 2HCl | CDK |
THZ1 (CDK7 inhibitor) is a novel selective and potent covalent CDK7 inhibitor. | |||
T7296 | THZ2 | CDK7-IN-1 | CDK |
THZ2 (CDK7-IN-1), an analog of THZ1, is a potent and selective CDK7 inhibitor(IC50:13.9 nM),with the potential to treat Triple-negative breast cancer (TNBC). | |||
T22461 | YKL-5-124 | CDK | |
YKL-5-124, a potent, selective and covalent CDK7 inhibitor with an IC50 of 9.7 nM, 1300 nM and 3020 nM for CDK7/Mat1/CycH, CDK2 and CDK9 respectively, displays biochemical and cellular selectivity for CDK7 over CDK12/13... | |||
T13044 | Mevociclib | SY-1365 | CDK |
Mevociclib (SY-1365) is a highly selective covalent inhibitor of CDK7. SY-1365 possesses therapeutic potential in both hematological and solid tumors. | |||
T10898 | Samuraciclib hydrochloride | ICEC0942 hydrochloride,CT7001 hydrochloride | Apoptosis , CDK |
Samuraciclib hydrochloride (ICEC0942 hydrochloride) is a potent, selective, ATP competitive and oral active CDK7 inhibitor with IC50 of 41 nM. The selectivity of Samuraciclib hydrochloride is 45-, 15-, 230- and 30-fold h... | |||
T4051 | LDC4297 | LDC044297 | CDK , HSV |
LDC4297 (LDC044297) is a potent and selective CDK7 inhibitor. | |||
T4417 | LDC-4297 HCl (1453834-21-3(free base)) | CDK | |
LDC4297 is a potent and selective CDK7 inhibitor with an IC50 of 0.13 nM. | |||
T22440 | TP-353 | EOS-61973 | CDK |
TP-353 (EOS-61973) is a CDK7 inhibitor. | |||
T36038 | SY-5609 | CDK7-IN-3 | CDK |
SY-5609 is a selective and noncovalent inhibitor of CDK7(KD = 0.065 nM) with antitumor activity and inhibits apoptosis. | |||
T2095 | Seliciclib | Roscovitine,R-roscovitine,CYC202 | CDK |
Seliciclib (Roscovitine) is a potent inhibitor of Cdk2/cyclin E (IC50: 0.1 μM). It also inhibits Cdk7/cyclin H, Cdk5/p35, and Cdc2/cyclin B (IC50s: 0.49/0.16/0.65 μM). | |||
T6162 | BS-181 hydrochloride | BS-181 HCl | CDK |
BS-181 hydrochloride (BS-181 HCl) is a highly selective CDK7 inhibitor with IC50 of 21 nM. It is more than 40-fold selective for CDK7 than CDK1, 2, 4, 5, 6, or 9. | |||
T35332 | THZ1 2HCl | THZ1 2HCl,THZ1 Dihydrochloride | CDK |
THZ1 2HCl (THZ1 Dihydrochloride) is a selective, covalent, and allosteric inhibitor of CDK7 with an IC50 of 3.2 nM. THZ1 2HCl has antiproliferative effects on a variety of cancer cell lines. | |||
TQ0060 | LY2857785 | Apoptosis , CDK | |
LY2857785 is a type I competitive and reversible ATP kinase inhibitor against CDK7/CDK8/CDK9 (IC50s: 246 nM/16 nM/11 nM). | |||
T6205 | AT7519 | Apoptosis , GSK-3 , CDK | |
AT7519 is a CDK1/2/4/6/9 inhibitor (IC50: 10-210 nM). It is less effective to CDK3 and little active to CDK7. | |||
T39752 | CDK12-IN-2 | CDK12 inhibitor 2,CDK12-IN-2 | CDK |
CDK12-IN-2 (CDK12 inhibitor 2) is an effective and selective inhibitor of CDK12 with an IC50 of 52 nM, >100 μM, >10 μM and 16 μM for CDK12, CDK2, CDK7, and CDK9. CDK12-IN-2 can be used in studies about the function of CD... | |||
T6049 | SNS-032 | SNS032,BMS-387032 | Apoptosis , GSK-3 , CDK |
SNS-032 (BMS-387032) is a selective inhibitor of CDK2 (IC50: 48 nM ) and is 10- and 20-fold selective over CDK1/CDK4. It is also sensitive to CDK7/9 (IC50: 62 nM/4 nM), and no effect on CDK6. | |||
T6312 | R547 | Ro 4584820 | Apoptosis , GSK-3 , PKA , CDK |
R547 (Ro 4584820) is a potent ATP-competitive inhibitor of CDK1/2/4 with Ki of 2 nM/3 nM/1 nM. It is less potent to CDK7 and GSK3α/β, while inactive to other kinases. Phase 1. | |||
T2378 | RGB-286638 free base | GSK-3 , MEK , JAK , CDK | |
RGB-286638 free base is a novel CDK inhibitor with IC50s of 1 nM/2 nM/3 nM/4 nM/5 nM for cyclin T1-CDK9/cyclin B1-CDK1/cyclin E-CDK2/cyclin D1-CDK4/cyclin E-CDK3/p35-CDK5 respectively; less potent against cyclin H-CDK7 a... | |||
T14943 | CGP60474 | VEGFR , CDK , PKC | |
CGP60474 is an inhibitor of VEGFR-2 (IC50 = 84 nM) and an inhibitor of ATP-competitive PKC. CGP60474 is also a highly potent anti-endotoxemic agent and inhibits cyclin-dependent kinase (CDK) potently. | |||
T27805 | LDC3140 | LDC 3140,LDC-3140,LDC043140 | |
LDC3140 is a potent inhibitor of Cyclin-dependent kinase 7 (CDK7). |